SUBSET SPECIFICATION
This option lets you choose between the alignment with all the known GPCR class A sequences
from different species, and the alignment with only human class A sequences.
The complete class A alignment contains fragments, isoforms and cDNA sequences, which have been filtered out of the human dataset,
as well as orphan and olfactory protein sequences.
The human alignment does allow a more extensive investigation of the sequences, because it contains more residues of the loops between the helices.
Comparison of the alignments:
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Complete class A:
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Human class A:
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Helix 1
Helix 2
Helix 3
Helix 4
Helix 5
Helix 6
Helix 7
Helix 8
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1.30 to 1.59
2.38 to 2.67
3.21 to 3.55
4.40 to 4.61
5.36 to 5.65
6.26 to 6.60
7.34 to 7.53
8.46 to 8.58
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1.27 to 1.60
2.37 to 2.68
3.21 to 3.56
4.38 to 4.64
5.35 to 5.77
6.25 to 6.66
7.33 to 7.55
8.47 to 8.64
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